Cover art by Steve Ditko. First appearance of the Sinister Six (Doctor Octopus, Electro, Kraven the Hunter, Mysterio, Sandman, and the Vulture) in a new 41-page story, "The Sinister Six!". Script by Stan Lee, art by Steve Ditko; Dr. Octopus organizes the Sinister Six, composed of other Spider-Man Villains; They capture Betty Brant and Aunt May and force Spider-Man to rescue them.
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