It is considered one of the three major religious orders, along with the Teutonic Knights and the Knights Templar. In 1271, their base, the castle of Krak-des-Chevaliers in Syria, was taken by Baibars of the Mamluk sultanate, and in 1291, the Crusader army's last stronghold, Accon, fell, forcing them to withdraw from the Holy Land.
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